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Walnut consumption increases activation of the insula to highly desirable food cues: A randomized, double‐blind, placebo‐controlled, cross‐over fMRI study.

Authors: Farr, O. M., Tuccinardi, D., Upadhyay, J., Oussaada, S. M., & Mantzoros, C. S. Journal: Diabetes Obes Metab Year: 2017 Pages: doi: 10.1111/dom.13060.
Fruits: Walnuts
Subject: Diabetes · Appetite

AIMS: The use of walnuts is recommended for obesity and type 2 diabetes, although the mechanisms through which walnuts may improve appetite control and/or glycaemic control remain largely unknown. MATERIALS AND METHODS: To determine whether short-term walnut consumption could alter the neural control of appetite using functional magnetic resonance imaging, we performed a randomized, placebo-controlled, double-blind, cross-over trial of 10 patients who received, while living in the controlled environment of a clinical research center, either walnuts or placebo (using a validated smoothie delivery system) for 5 days each, separated by a wash-out period of 1 month. RESULTS: Walnut consumption decreased feelings of hunger and appetite, assessed using visual analog scales, and increased activation of the right insula to highly desirable food cues. CONCLUSIONS: These findings suggest that walnut consumption may increase salience and cognitive control processing of highly desirable food cues, leading to the beneficial metabolic effects observed.
 

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